Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 5/20 | 0.67 |
| ▸ | TACR1 | P25103 | 3/20 | 0.67 |
| ▸ | TACR3 | P29371 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14089179 | 0.86 | TACR2 (0.75) | TACR2TACR1TACR3 | |
| SCHEMBL7870009 | 0.86 | TACR2 (0.73) | TACR2TACR1TACR3 | |
| SCHEMBL6952599 | 0.86 | TACR2 (0.73) | TACR2TACR1TACR3 | |
| SCHEMBL6588311 | 0.82 | TACR2 (0.69) | TACR2TACR1TACR3 | |
| SCHEMBL7870048 | 0.81 | TACR2 (0.67) | TACR2TACR1TACR3 | |
| SCHEMBL6033897 | 0.81 | TACR2 (0.64) | TACR2TACR1TACR3 | |
| SCHEMBL6160860 | 0.80 | TACR2 (0.62) | TACR2TACR1TACR3 | |
| SCHEMBL7312636 | 0.80 | TACR2 (0.66) | TACR2TACR1TACR3 | |
| SCHEMBL8482847 | 0.80 | TACR2 (0.66) | TACR2TACR1TACR3 | |
| Saredutant SCHEMBL185911 | 0.80 | TACR2 (1.00) | TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709376-B1 | Phenylpiperidino derivatives as neurokinin antagonists | ASTRAZENECA AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| US-6573381-B1 | Useful as intermediates, notably for the synthesis of methyl (S)-2(2-chlorophenyl)-2(4,5,6,7-tetrahydrothieno(3,2-c)-5-pyridyl)acetate or clopidrogel | SANOFI-SYNTHELABO (FR) | 2003-06-03 | — | — | US | disclosed |
| US-6008223-A | ANTIINFLAMMATORY AGENTS FOR TREATING ASTHMA | ZENECA LIMITED (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5731309-A | Substituted heteroalkyleneamine neurokinin antagonists | ZENECA LIMITED (GB) | 1998-03-24 | — | — | US | disclosed |
| EP-0709376-A2 | Therapeutic compounds | ZENECA LIMITED (GB) | 1996-05-01 | — | — | EP | disclosed |