Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949346 | 0.91 | CNR1 (0.46) | CNR1ALOX15TP53 | |
| SCHEMBL6951362 | 0.89 | CNR1 (0.44) | KDM4EGAATSHRHTTRAB9A | |
| SCHEMBL6953598 | 0.86 | CNR1 (0.41) | CNR1ALOX15 | |
| SCHEMBL7505102 | 0.86 | ALDH1A1 (0.51) | GAATSHRHSD17B10CNR1ALOX15 | |
| SCHEMBL6951356 | 0.85 | MEN1 (0.43) | KDM4EGAARAB9ANPSR1CNR1 | |
| SCHEMBL7503731 | 0.84 | KDM4E (0.50) | KDM4ERAB9ACNR1ALOX15TP53 | |
| SCHEMBL7512358 | 0.84 | ALOX15 (0.43) | CNR1ALOX15TP53 | |
| SCHEMBL7503003 | 0.83 | KDM4E (0.54) | KDM4EGAATSHRRAB9ANPSR1 | |
| SCHEMBL7509254 | 0.83 | ALDH1A1 (0.49) | KDM4ETSHRHSD17B10CNR1ALOX15 | |
| SCHEMBL6953063 | 0.83 | MEN1 (0.46) | KDM4EGAARAB9ANPSR1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | claimed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | claimed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | disclosed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | disclosed |