Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951187 | 1.00 | SIGMAR1 (0.52) | SIGMAR1HRH2CHRM2CHRM4CHRM5 | |
| SCHEMBL8220899 | 0.86 | NPC1 (0.55) | MEN1KMT2A | |
| SCHEMBL8220896 | 0.86 | NPC1 (0.55) | MEN1KMT2A | |
| SCHEMBL6043447 | 0.82 | SIGMAR1 (0.49) | SIGMAR1HRH2CHRM2CHRM4CHRM5 | |
| SCHEMBL6043441 | 0.82 | SIGMAR1 (0.49) | SIGMAR1HRH2CHRM2CHRM4CHRM5 | |
| SCHEMBL6043661 | 0.78 | SIGMAR1 (0.44) | SIGMAR1HRH2CHRM2CHRM4CHRM5 | |
| SCHEMBL6043652 | 0.78 | SIGMAR1 (0.44) | SIGMAR1HRH2CHRM2CHRM4CHRM5 | |
| SCHEMBL27506178 | 0.75 | HRH3 (0.53) | — | |
| SCHEMBL238334 | 0.74 | MEN1 (0.66) | SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL19066024 | 0.73 | MEN1 (0.65) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |