Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220899 | 1.00 | NPC1 (0.55) | NPC1RAB9AS1PR5GRIN1GRIN2B | |
| SCHEMBL1941470 | 0.88 | HRH3 (0.53) | NPC1RAB9AS1PR5GRIN1GRIN2B | |
| SCHEMBL27506178 | 0.88 | HRH3 (0.53) | NPC1RAB9AS1PR5GRIN1GRIN2B | |
| SCHEMBL6951192 | 0.86 | SIGMAR1 (0.52) | MEN1KMT2A | |
| SCHEMBL6951187 | 0.86 | SIGMAR1 (0.52) | MEN1KMT2A | |
| SCHEMBL1941467 | 0.79 | FDFT1 (0.47) | NPC1RAB9AS1PR5FDFT1MAPK1 | |
| SCHEMBL8218213 | 0.79 | FDFT1 (0.47) | NPC1RAB9AS1PR5FDFT1MAPK1 | |
| SCHEMBL8218218 | 0.79 | FDFT1 (0.47) | NPC1RAB9AS1PR5FDFT1MAPK1 | |
| SCHEMBL28103955 | 0.74 | FDFT1 (0.45) | NPC1RAB9AS1PR5HRH3FDFT1 | |
| SCHEMBL8214501 | 0.74 | NPC1 (0.56) | NPC1RAB9AHRH3TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000063173-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PIPERIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-26 | — | — | WO | disclosed |