Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | ADK | P55263 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | F2RL1 | P55085 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953526 | 0.85 | CFTR (0.46) | ADRA2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL6954460 | 0.85 | CFTR (0.46) | ADRA2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL6954666 | 0.85 | F2RL1 (0.43) | ADRA2AADRA2BADRA2CF2RL1 | |
| SCHEMBL9386046 | 0.82 | NISCH (0.44) | MTORADKNISCHADRA2AADRA2B | |
| SCHEMBL6934137 | 0.82 | TAAR1 (0.52) | MTORADKNISCHADRA2AADRA2B | |
| SCHEMBL954734 | 0.82 | CHRM2 (0.45) | MTORADKNISCHADRA2AADRA2B | |
| SCHEMBL953334 | 0.79 | CHRM2 (0.43) | MTORADKNISCHADRA2AADRA2B | |
| SCHEMBL9659736 | 0.79 | HRH1 (0.55) | MTORADKNISCHADRA2AADRA2B | |
| SCHEMBL6956313 | 0.79 | F2RL1 (0.50) | MTORADKNISCHADRA2AADRA2B | |
| SCHEMBL8165342 | 0.79 | ADRA2A (0.48) | MTORADKNISCHADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276725-A2 | 5-SUBSTITUTED TETRALONES AS INHIBITORS OF RAS FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001079180-A2 | 5-SUBSTITUTED TETRALONES AS INHIBITORS OF RAS FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 2001-10-25 | — | — | WO | disclosed |