Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.50 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5562101 | 0.83 | MEN1 (0.39) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL4602631 | 0.83 | MEN1 (0.39) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL6949144 | 0.83 | GPR119 (0.39) | MEN1KMT2A | |
| SCHEMBL7075359 | 0.83 | MEN1 (0.43) | SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL6958285 | 0.82 | — | — | |
| SCHEMBL6947706 | 0.82 | MEN1 (0.38) | SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL6954303 | 0.82 | MEN1 (0.38) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL7081812 | 0.82 | NPC1 (0.40) | PDE4BMEN1KMT2A | |
| SCHEMBL6950872 | 0.82 | HTT (0.45) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL6960005 | 0.81 | MEN1 (0.39) | SLC6A2SLC6A4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |