Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 6/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 6/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813061 | 0.80 | PTPN1 (0.46) | PTPN1METAP2KDM4EDYRK1ARECQL | |
| SCHEMBL30729983 | 0.79 | TDP1 (0.41) | MGAMMETAP2KDM4ENPC1RAB9A | |
| SCHEMBL4995210 | 0.75 | PARP1 (0.51) | PTPN1METAP2KDM4ERECQLMEN1 | |
| SCHEMBL698486 | 0.72 | MGAM (0.42) | MGAMPTPN1KDM4ERECQLTDP1 | |
| SCHEMBL694559 | 0.71 | KDM4E (0.53) | METAP2KDM4ERECQLNPC1RAB9A | |
| SCHEMBL30270547 | 0.69 | CTNNB1 (0.65) | METAP2KDM4EDYRK1ANPC1RAB9A | |
| SCHEMBL261380 | 0.69 | CTNNB1 (0.65) | METAP2KDM4EDYRK1ANPC1RAB9A | |
| SCHEMBL17204225 | 0.69 | KDM4E (0.39) | MGAMKDM4EDYRK1ARECQLNPC1 | |
| SCHEMBL10465639 | 0.69 | MGAM (0.70) | MGAMKDM4ENPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL1665151 | 0.68 | CTNNB1 (0.63) | METAP2KDM4EDYRK1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421864-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122272-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-10-28 | — | — | WO | disclosed |