Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 5/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695375 | 0.72 | MGAM (0.43) | MGAMPARP1PTPN1CSNK2A1CSNK2A2 | |
| SCHEMBL5174792 | 0.72 | TDP1 (0.53) | KDM4ETDP1HSP90AA1ESR2 | |
| SCHEMBL25401469 | 0.68 | TDP1 (0.53) | KDM4ERECQLTDP1HSP90AA1ESR2 | |
| SCHEMBL1759259 | 0.68 | MGAM (0.47) | MGAMKDM4ETDP1GABRPGABRD | |
| SCHEMBL10465639 | 0.68 | MGAM (0.70) | MGAMKDM4EPDGFRBPDGFRATDP1 | |
| SCHEMBL28563733 | 0.67 | TDP1 (0.47) | MGAMCSNK2A2KDM4ECSNK2BTDP1 | |
| SCHEMBL28327537 | 0.67 | KDM4E (0.55) | MGAMPARP1PTPN1CSNK2A1CSNK2A2 | |
| SCHEMBL69368 | 0.66 | MGAM (0.68) | MGAMKDM4EPDGFRBPDGFRATDP1 | |
| SCHEMBL14320411 | 0.66 | KMT2A (0.40) | KDM4EPDGFRBPDGFRATDP1 | |
| SCHEMBL4995210 | 0.65 | PARP1 (0.51) | PARP1PTPN1CSNK2A1CSNK2A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421864-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122272-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-10-28 | — | — | WO | disclosed |