SCHEMBL261380

SCHEMBL261380

O=C(O)c1ccc2[nH]ncc2c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 6/20 0.65
WNT3A P56704 6/20 0.65
RAB9A P51151 3/20 0.55
NPC1 O15118 2/20 0.55
JAK2 O60674 1/20 0.55
MAOB P27338 3/20 0.54
ROCK2 O75116 4/20 0.53
ROCK1 Q13464 4/20 0.53
CLK2 P49760 2/20 0.52
DYRK1A Q13627 2/20 0.52
CLK4 Q9HAZ1 2/20 0.52
PRKD3 O94806 1/20 0.52
MAP4K4 O95819 1/20 0.52
RPS6KB1 P23443 1/20 0.52
PRKG1 Q13976 1/20 0.52
PRKD2 Q9BZL6 1/20 0.52
SGK2 Q9HBY8 1/20 0.52
STK17A Q9UEE5 1/20 0.52
NOS1 P29475 3/20 0.52
METAP2 P50579 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30270547 1.00 CTNNB1 (0.65) CTNNB1WNT3ARAB9ANPC1JAK2
Hydrochloric Acid SCHEMBL1665151 0.98 CTNNB1 (0.63) CTNNB1WNT3ARAB9ANPC1JAK2
Trifluoroacetic Acid SCHEMBL27736715 0.91 CTNNB1 (0.56) CTNNB1WNT3ARAB9ANPC1JAK2
SCHEMBL31253099 0.86 GSK3B (0.68) CTNNB1WNT3ARAB9ANPC1JAK2
SCHEMBL23063810 0.86 GSK3B (0.68) CTNNB1WNT3ARAB9ANPC1JAK2
SCHEMBL260992 0.85 ALDH1A1 (0.56) CTNNB1WNT3AMAOBCLK2DYRK1A
SCHEMBL29365815 0.85 ALDH1A1 (0.56) CTNNB1WNT3AMAOBCLK2DYRK1A
SCHEMBL1419814 0.84 AR (0.63) CTNNB1WNT3ARAB9ANPC1JAK2
SCHEMBL20187077 0.84 CTNNB1 (0.59) CTNNB1WNT3ARAB9ANPC1JAK2
Hydrochloric Acid SCHEMBL7001071 0.84 ALDH1A1 (0.55) CTNNB1WNT3AMAOBCLK2DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 629 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036615-A Indazole hydrazide compound and preparation method and application thereof 南京农业大学 2026-05-15 CN claimed
CN-119285974-A Zinc-based metal organic framework material and preparation method and application thereof 北京化工大学 2025-01-10 CN claimed
CN-117696012-A Metal organic framework material and preparation method and application thereof 浙江大学 2024-03-15 CN claimed
CN-117050300-A Polylysine-based polymer adjuvant material, and preparation method and application thereof 中国科学院长春应用化学研究所 2023-11-14 CN claimed
CN-113603886-A Polyethyleneimine derivative and preparation method and application thereof 中国科学院长春应用化学研究所 2021-11-05 CN claimed
EP-3288940-B9 AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2021-07-21 EP claimed
EP-3288940-B1 AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2021-02-24 EP claimed
US-10604493-B2 Compositions, methods of use, and methods of treatment UNIVERSITY OF SOUTH FLORIDA (US) 2020-03-31 US claimed
US-7674795-B2 Fluorene derivatives, composition containing said derivatives and the use thereof AVENTIS PHARMA SA (FR) 2010-03-09 US claimed
EP-1628972-B1 INDAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS SANOFI AVENTIS DEUTSCHLAND (DE) 2009-04-22 EP claimed
US-20080153837-A1 Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof AVENTIS PHARMA S.A. (FR) 2008-06-26 US claimed
CN-1200110-C Method of preparing non protein source L-amino acid INTERNAT ELECTROMECHANICAL IND (DE) 2005-05-04 CN claimed
US-6579705-B2 Generating preferential amino acid sequences; obtain adjusted amino acid, incubate with enzyme, recover amino acid CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 2003-06-17 US claimed
US-20020177196-A1 Process for preparing non-proteinogenic L-amino acids CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH 2002-11-28 US claimed
CN-1379111-A Method of preparing non protein source L-amino acid INTERNAT ELECTROCHEMICAL INDUS (DE) 2002-11-13 CN claimed
EP-1247869-A1 Process for the production of non-proteinogenic amino acids Consortium für elektrochemische Industrie GmbH (DE) 2002-10-09 EP claimed
JP-11228513-A None JP disclosed
CN-122036615-A Indazole hydrazide compound and preparation method and application thereof 南京农业大学 2026-05-15 CN disclosed
JP-H11228513-A 4-ACETYLAMINO-3-METHYLBENZOIC ACID COMPOUND, ITS PRODUCTION AND PRODUCTION OF 1H-INDAZOLE-5-CARBOXYLIC ACID USING THE SAME SUMIKA FINE CHEMICALS CO LTD 1999-08-24 JP disclosed
EP-0573218-A2 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use SANKYO COMPANY LIMITED (JP) 1993-12-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10604493-B2 Compositions, methods of use, and methods of treatment LIPA, LCT, GAA CTNNB1 529/4885WNT3A 2657/4885RAB9A 2492/4885
US-20080153837-A1 Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof HSP90B1, HSP90AB1, HSP90AA1 CTNNB1 2510/4885WNT3A 4015/4885RAB9A 1012/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.