Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953995 | 1.00 | KDM1A (0.56) | KDM1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL6958651 | 0.99 | KDM1A (0.55) | KDM1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL6958654 | 0.99 | KDM1A (0.55) | KDM1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21460365 | 0.78 | KDM1A (0.60) | KDM1ASLC6A2SLC6A4SLC6A3MAOA | |
| SCHEMBL3333986 | 0.77 | HTR1A (0.50) | KDM1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29698867 | 0.77 | HTR1A (0.50) | KDM1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27880809 | 0.77 | HTR1A (0.50) | KDM1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30368779 | 0.77 | HTR1A (0.61) | KDM1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL233327 | 0.77 | HTR1A (0.61) | KDM1AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6966294 | 0.76 | GHSR (0.43) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |