Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 6/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15202523 | 0.84 | STS (0.44) | CTSSCTSLCTSBCTSKMEN1 | |
| SCHEMBL695875 | 0.84 | GPR119 (0.49) | GPR119HTR2AHTR2CHTR2BPIK3CD | |
| SCHEMBL695226 | 0.81 | CTSS (0.54) | CTSSCTSLCTSB | |
| SCHEMBL15200555 | 0.78 | STS (0.47) | CTSSCTSLCTSBCTSK | |
| SCHEMBL694346 | 0.78 | STS (0.44) | CTSSCTSLCTSBCTSK | |
| SCHEMBL707038 | 0.76 | CTSS (0.46) | CTSSCTSLCTSBCTSK | |
| SCHEMBL695061 | 0.76 | CTSS (0.44) | CTSSCTSLCTSBCTSK | |
| SCHEMBL696865 | 0.76 | CTSS (0.41) | CTSSCTSLCTSBCTSK | |
| SCHEMBL697234 | 0.76 | CTSS (0.55) | L3MBTL1CTSSCTSLCTSBCTSK | |
| SCHEMBL696265 | 0.76 | CTSS (0.46) | CTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |