Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959336 | 0.88 | KMT2A (0.39) | MEN1KMT2AMRGPRX4KLK7 | |
| SCHEMBL7078323 | 0.85 | REN (0.45) | REN | |
| SCHEMBL6041884 | 0.82 | MRGPRX4 (0.39) | RENMEN1KMT2ABCHEMRGPRX4 | |
| SCHEMBL7076957 | 0.82 | MC4R (0.36) | RENTACR1 | |
| SCHEMBL6957468 | 0.81 | MC4R (0.37) | RENTACR1 | |
| SCHEMBL6953032 | 0.81 | BACE1 (0.39) | BACE1BACE2 | |
| SCHEMBL6952166 | 0.81 | REN (0.41) | RENMEN1KMT2A | |
| SCHEMBL6959615 | 0.81 | KDM4E (0.40) | MEN1KMT2A | |
| SCHEMBL6950788 | 0.80 | MEN1 (0.33) | MEN1KMT2ATACR1CHRM3 | |
| SCHEMBL6949602 | 0.80 | GPR119 (0.39) | MEN1KMT2ABACE1BACE2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |