Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799522 | 0.90 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2FDFT1TSHRPOLB | |
| SCHEMBL6956337 | 0.90 | FDFT1 (0.39) | FDFT1 | |
| SCHEMBL6954346 | 0.80 | MAPT (0.39) | ALDH1A1SMN1; SMN2FDFT1TSHRMAPT | |
| SCHEMBL6954335 | 0.80 | MAPT (0.39) | ALDH1A1SMN1; SMN2FDFT1TSHRMAPT | |
| SCHEMBL8799237 | 0.78 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2FDFT1TSHRMAPT | |
| SCHEMBL6957312 | 0.78 | FDFT1 (0.50) | FDFT1 | |
| SCHEMBL6957317 | 0.78 | FDFT1 (0.50) | FDFT1 | |
| SCHEMBL6957323 | 0.78 | FDFT1 (0.50) | FDFT1 | |
| SCHEMBL8800495 | 0.77 | FDFT1 (0.38) | ALDH1A1SMN1; SMN2FDFT1TSHRPOLB | |
| SCHEMBL8505447 | 0.77 | FDFT1 (0.43) | FDFT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567026-B1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5885979-A | SQUALENE SYNTHETASE INHIBITOR TREATING OR PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5726306-A | INHIBITORS OF SQUALENE SYNTHETASE AND FUNGAL GROWTH; USEFUL IN TREATING AND PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0567026-A1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |