Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954342 | 0.90 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2FDFT1TSHRPOLB | |
| SCHEMBL8799237 | 0.88 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2FDFT1TSHRMAPT | |
| SCHEMBL8800495 | 0.86 | FDFT1 (0.38) | ALDH1A1SMN1; SMN2FDFT1TSHRPOLB | |
| SCHEMBL6956337 | 0.83 | FDFT1 (0.39) | FDFT1 | |
| SCHEMBL6954335 | 0.81 | MAPT (0.39) | ALDH1A1SMN1; SMN2FDFT1TSHRMAPT | |
| SCHEMBL6954346 | 0.81 | MAPT (0.39) | ALDH1A1SMN1; SMN2FDFT1TSHRMAPT | |
| SCHEMBL6957312 | 0.78 | FDFT1 (0.50) | FDFT1 | |
| SCHEMBL6957317 | 0.78 | FDFT1 (0.50) | FDFT1 | |
| SCHEMBL6957323 | 0.78 | FDFT1 (0.50) | FDFT1 | |
| SCHEMBL6951630 | 0.77 | FDFT1 (0.39) | FDFT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677298-A | USEFUL FOR THE PROPHYLAXIS OR THERAPY OF HYPERCHOLESTEREMIA OR CORONOARY SCLEROSIS OF MAMMALS | TAKEDA CHEMICAL INDUSTRIES (JP) | 1997-10-14 | — | — | US | disclosed |
| EP-0645377-B1 | Benzoxazepine derivatives useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-08-13 | — | — | EP | disclosed |
| EP-0645377-A1 | Benzoxazepine derivatives useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-29 | — | — | EP | disclosed |