Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 13/20 | 0.40 |
| ▸ | ACHE | P22303 | 13/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122861 | 0.85 | ACHE (0.36) | BCHEACHE | |
| SCHEMBL8128249 | 0.84 | ACHE (0.37) | BCHEACHE | |
| SCHEMBL8127299 | 0.83 | MEN1 (0.35) | BCHEACHE | |
| SCHEMBL8122765 | 0.82 | ACHE (0.34) | BCHEACHE | |
| SCHEMBL8121921 | 0.80 | ALDH1A1 (0.34) | BCHEACHE | |
| SCHEMBL6953068 | 0.79 | ACHE (0.33) | ACHE | |
| SCHEMBL6952130 | 0.78 | SMN1; SMN2 (0.36) | BCHEACHE | |
| SCHEMBL8113406 | 0.77 | SMN1; SMN2 (0.36) | BCHEACHE | |
| SCHEMBL6951581 | 0.69 | BCHE (0.43) | BCHEACHEHRH3 | |
| SCHEMBL6947707 | 0.69 | KDM4E (0.42) | BCHEACHEHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074549-B1 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | HOFFMANN LA ROCHE (CH) | 2003-11-19 | — | — | EP | disclosed |
| US-6218385-B1 | FOR THERAPY OR PROPHYLAXIS OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS SUCH AS EPILEPSY, STROKE, CHRONIC AND ACUTE PAIN, PSYCHOSIS, SCHIZOPHRENIA, ALZHEIMER'S DISEASE, COGNITIVE DISORDERS AND MEMORY DEFICITS | HOFFMANN-LA ROCHE INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1074549-A2 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-07 | — | — | EP | disclosed |