Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 11/20 | 0.46 |
| ▸ | DRD2 | P14416 | 10/20 | 0.46 |
| ▸ | DRD4 | P21917 | 10/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.46 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499273 | 0.85 | SLC6A1 (0.52) | DRD3DRD2DRD4CHRM2CHRM1 | |
| Potassium Ion SCHEMBL6957972 | 0.84 | CHRM2 (0.47) | DRD3DRD2DRD4CHRM2CHRM1 | |
| SCHEMBL8196728 | 0.80 | SLC6A1 (0.63) | DRD2SLC6A1HTR1A | |
| SCHEMBL8196471 | 0.80 | SLC6A1 (0.63) | DRD2SLC6A1HTR1A | |
| SCHEMBL6961863 | 0.80 | CHRM2 (0.57) | DRD3DRD2DRD4CHRM2CHRM1 | |
| SCHEMBL6968486 | 0.80 | DRD3 (0.46) | DRD3DRD2DRD4CHRM2CHRM1 | |
| SCHEMBL8199176 | 0.78 | SLC6A1 (0.63) | DRD2SLC6A1HTR1A | |
| SCHEMBL6967020 | 0.78 | SLC6A1 (0.49) | DRD3DRD2DRD4CHRM2CHRM1 | |
| SCHEMBL8187340 | 0.78 | SLC6A1 (0.59) | DRD2SLC6A1HTR1A | |
| SCHEMBL7172628 | 0.78 | CHRM2 (0.54) | DRD3DRD2DRD4CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613791-B1 | Treating migraine, neurogenic inflammation, rheumatoid arthritis or insulin resistance | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-0820451-B1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK AS (DK) | 2003-01-15 | — | — | EP | disclosed |
| US-6239148-B1 | TREATMENT OF PAINFUL, HYPERALGESIC AND/OR INFLAMMATORY CONDITIONS IN WHICH C-FIBERS PLAY A ROLE BY ELICITING NEUROGENIC PAIN, INSULIN RESISTANCE IN DIABETES MELLITUS OR AGING, INHIBIT INSULIN ANTAGONIZING PEPTIDE, | NOVO NORDISK A/S (DK) | 2001-05-29 | — | — | US | disclosed |
| US-6166009-A | N-substituted azaheterocyclic carboxylic acids and esters thereof | NOVO NORDISK A/S (DK) | 2000-12-26 | — | — | US | disclosed |
| US-6110913-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | NOVO NORDISK A/S (DK) | 2000-08-29 | — | — | US | disclosed |
| US-6071901-A | TREATING PAIN, HYPERALGESIA AND/OR INFLAMMATORY CONDITIONS IN WHICH C-FIBERS PLAY A PATHOPHYSIOLOGICAL ROLE; INHIBITION OF NEUROGENIC INFLAMMATION INVOLVING THE RELEASE OF NEURO-PEPTIDE FROM PERIPHERAL AND CENTRAL ENDINGS OF SENSORY NERVES | NOVO NORDISK A/S (DK) | 2000-06-06 | — | — | US | disclosed |
| EP-0820451-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031498-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1996-10-10 | — | — | WO | disclosed |