Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CRHBP | P24387 | 2/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965769 | 0.79 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL19439043 | 0.73 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL29280749 | 0.72 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL8789867 | 0.72 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL27036962 | 0.71 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL3336144 | 0.70 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL6368585 | 0.70 | MEN1 (0.52) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL6955073 | 0.70 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL6368579 | 0.70 | MEN1 (0.52) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL8790477 | 0.70 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2LMNACRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |