Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789867 | 0.86 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL8790477 | 0.84 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL27448293 | 0.82 | CRHBP (0.57) | ALDH1A1SMN1; SMN2LMNACYP2C19CRHBP | |
| SCHEMBL11431170 | 0.76 | PLA2G4B (0.68) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL6046672 | 0.76 | RAB9A (0.54) | ALDH1A1SMN1; SMN2LMNACYP2C19CRHBP | |
| SCHEMBL8479238 | 0.76 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL656493 | 0.75 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL6965764 | 0.75 | CYP2C9 (1.00) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL1016036 | 0.75 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 | |
| SCHEMBL6321927 | 0.75 | ALOX5 (0.62) | ALDH1A1SMN1; SMN2LMNACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| CN-1071746-C | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 2001-09-26 | — | — | CN | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| CN-1132505-A | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 1996-10-02 | — | — | CN | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |