Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955083 | 1.00 | OPRD1 (0.60) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL6963522 | 0.86 | OPRM1 (0.58) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL6963525 | 0.86 | OPRM1 (0.58) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL10442726 | 0.81 | OPRD1 (0.60) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL8591005 | 0.81 | OPRD1 (0.63) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL11602782 | 0.79 | OPRM1 (0.66) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL6958608 | 0.78 | OPRM1 (0.58) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL6968528 | 0.78 | OPRM1 (0.58) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL6891511 | 0.78 | OPRM1 (0.69) | OPRD1OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL172642 | 0.78 | OPRM1 (0.61) | OPRD1OPRM1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |