Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.62 |
| ▸ | AGXT | P21549 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2022678 | 0.81 | LOXL2 (0.59) | LOXL2AGXTPSMB5PSMB8PIN1 | |
| SCHEMBL533908 | 0.77 | LOXL2 (1.00) | LOXL2AGXTHTR2BHTR1ACYP19A1 | |
| SCHEMBL8099960 | 0.77 | LOXL2 (0.54) | LOXL2AGXTPSMB5PSMB8PIN1 | |
| SCHEMBL5962355 | 0.77 | LOXL2 (0.58) | LOXL2AGXTPSMB5PSMB8PIN1 | |
| Hydrochloric Acid SCHEMBL6942058 | 0.76 | LOXL2 (0.96) | LOXL2AGXTHTR2BHTR1ACYP19A1 | |
| SCHEMBL7888402 | 0.76 | PIN1 (0.54) | LOXL2AGXTPSMB5PSMB8PIN1 | |
| SCHEMBL4784337 | 0.76 | PIN1 (0.54) | LOXL2AGXTPSMB5PSMB8PIN1 | |
| Hydrochloric Acid SCHEMBL8578217 | 0.74 | PIN1 (0.53) | LOXL2AGXTPSMB5PSMB8PIN1 | |
| SCHEMBL140395 | 0.74 | LOXL2 (0.71) | LOXL2AGXTHTR2BHTR1ACYP19A1 | |
| SCHEMBL11291792 | 0.74 | LOXL2 (0.55) | LOXL2AGXTPSMB5PSMB8PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |