Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7813972 | 0.98 | ALDH1A1 (0.49) | ALDH1A1KDM4ERECQLSMN1; SMN2MAPT | |
| Trifluoroacetic Acid SCHEMBL5901300 | 0.85 | ALDH1A1 (0.50) | ALDH1A1KDM4ERECQLSMN1; SMN2MAPT | |
| Trifluoroacetic Acid SCHEMBL6956793 | 0.85 | ALDH1A1 (0.50) | ALDH1A1KDM4ERECQLSMN1; SMN2MAPT | |
| SCHEMBL9080616 | 0.81 | CA1 (0.41) | ALDH1A1KDM4EMAPK1HTR6MEN1 | |
| SCHEMBL2104955 | 0.80 | ALDH1A1 (0.70) | ALDH1A1KDM4ERECQLSMN1; SMN2MAPT | |
| SCHEMBL311214 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4ERECQLSMN1; SMN2MAPT | |
| SCHEMBL20793136 | 0.80 | HTR6 (0.46) | ALDH1A1KDM4ERECQLSMN1; SMN2MAPT | |
| SCHEMBL20523354 | 0.80 | HTR6 (0.46) | ALDH1A1KDM4ERECQLSMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7814594 | 0.79 | CA1 (0.39) | ALDH1A1KDM4EHTR6MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL310655 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KDM4ERECQLSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871623-B1 | 3-AZETIDINYLALKYLPIPERIDINES OR -PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2003-02-12 | — | — | EP | disclosed |
| CN-1072666-C | (Azetidin-1-ylalkyl) lactams as tachykinin antagonists | PFIZER RES AND DEV CO N V S A (IE) | 2001-10-10 | — | — | CN | disclosed |
| US-6262046-B1 | Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists | PFIZER INC. | 2001-07-17 | — | — | US | disclosed |
| CN-1207096-A | 3-azetidinylalkylpiperidines or-pyrrolidines as tachykinin antagonists | PFIZER RES & DEV (IE) | 1999-02-03 | — | — | CN | disclosed |
| CN-1154699-A | (Azetidin-1-ylalkyl) lactams as tachykinin antagonists | PFIZER LTD (IE) | 1997-07-16 | — | — | CN | disclosed |