Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640752 | 0.92 | RAB9A (0.71) | ALDH1A1RAB9AMAPTKMT2AMAPK1 | |
| SCHEMBL1641800 | 0.89 | ALDH1A1 (0.79) | ALDH1A1RAB9AMAPTKMT2AMAPK1 | |
| SCHEMBL6956537 | 0.86 | RAB9A (0.82) | ALDH1A1RAB9AMAPTKMT2AMAPK1 | |
| SCHEMBL259383 | 0.79 | NPSR1 (0.78) | ALDH1A1RAB9AKMT2ALMNAHTT | |
| SCHEMBL11655759 | 0.77 | SMN1; SMN2 (0.80) | ALDH1A1RAB9AMAPTKMT2AMAPK1 | |
| SCHEMBL7808621 | 0.77 | SMN1; SMN2 (0.70) | ALDH1A1RAB9AMAPTKMT2AMAPK1 | |
| SCHEMBL1273971 | 0.77 | HTR2C (0.54) | RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL25228303 | 0.76 | RAB9A (1.00) | ALDH1A1RAB9AMAPTKMT2AMAPK1 | |
| SCHEMBL8123409 | 0.76 | KMT2A (0.68) | ALDH1A1RAB9AMAPTKMT2AMAPK1 | |
| SCHEMBL14266467 | 0.76 | KMT2A (0.77) | ALDH1A1RAB9AMAPTKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337253-A1 | NOVEL COMPOUNDS | GlaxoSmithKline S.p.A. (IT) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002043734-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE SPA (IT) | 2002-06-06 | — | — | WO | disclosed |