SCHEMBL695567

SCHEMBL695567

N#Cc1ccc(Sc2cc(Cl)cc(Cl)c2)c(N)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.47
SLC6A4 P31645 1/20 0.47
SLC6A3 Q01959 1/20 0.47
KDM4E B2RXH2 4/20 0.44
MAPT P10636 3/20 0.44
HPGD P15428 3/20 0.44
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
CYP1A2 P05177 3/20 0.44
CYP3A4 P08684 3/20 0.44
CYP2C19 P33261 3/20 0.44
CYP2D6 P10635 2/20 0.44
MAOA P21397 5/20 0.43
MAOB P27338 5/20 0.43
AR P10275 1/20 0.40
ALDH1A1 P00352 3/20 0.37
LMNA P02545 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3100801 0.87 TRPV4 (0.39) SLC6A2SLC6A4SLC6A3KDM4EMAPT
SCHEMBL16676222 0.80 KDM4E (0.57) SLC6A2SLC6A4SLC6A3KDM4EMAPT
SCHEMBL694015 0.78 SLC6A2 (0.48) SLC6A2SLC6A4SLC6A3KDM4EMAPT
SCHEMBL694090 0.76 TRPV4 (0.44) KDM4EMAPTHPGDMEN1KMT2A
SCHEMBL6516138 0.75 SLC6A2 (0.49) SLC6A2SLC6A4SLC6A3KDM4EMAPT
SCHEMBL695747 0.75 VCAM1 (0.57) L3MBTL1PDE7A
SCHEMBL2638690 0.73 ADORA2A (0.40) SLC6A2SLC6A4SLC6A3KDM4EMAPT
SCHEMBL3103805 0.73 VCAM1 (0.51) L3MBTL1PDE7A
SCHEMBL30873036 0.69 TSHR (0.50) SLC6A2SLC6A4SLC6A3KDM4ECYP3A4
SCHEMBL1026066 0.69 TSHR (0.50) SLC6A2SLC6A4SLC6A3KDM4ECYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2749554-B1 2,5-disubstituted arylsulfonamide CCR3 antagonists SMA THERAPEUTICS INC (US) 2017-12-20 EP disclosed
EP-2749554-B1 2,5-disubstituted arylsulfonamide CCR3 antagonists SMA THERAPEUTICS INC (US) 2017-12-20 EP disclosed
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2016-02-04 US disclosed
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2016-02-04 US disclosed
US-9187425-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-11-17 US disclosed
US-9187425-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2015-11-17 US disclosed
CN-102459177-B The dibasic Arylsulfonamide ccr 3 antagonists of 2,5- AXIKIN PHARMACEUTICALS, INC. (US) 2015-09-02 CN disclosed
EP-2749554-A2 2,5-disubstituted arylsulfonamide CCR3 antagonists Axikin Pharmaceuticals, Inc. (US) 2014-07-02 EP disclosed
EP-2749554-A2 2,5-disubstituted arylsulfonamide CCR3 antagonists Axikin Pharmaceuticals, Inc. (US) 2014-07-02 EP disclosed
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2014-03-06 US disclosed
US-8563544-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-10-22 US disclosed
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-03-14 US disclosed
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-03-14 US disclosed
US-8318747-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2012-11-27 US disclosed
US-8318747-B2 2,5-disubstituted arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2012-11-27 US disclosed
EP-2421830-A2 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS Axikin Pharmaceuticals, Inc. (US) 2012-02-29 EP disclosed
WO-2010123959-A2 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 WO disclosed
WO-2010123959-A2 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 WO disclosed
US-20100273785-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2010-10-28 US disclosed
US-20100273785-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. 2010-10-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031841-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 SLC6A2 2308/4885SLC6A4 1650/4885SLC6A3 427/4885
US-20100273785-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 SLC6A2 2439/4885SLC6A4 1745/4885SLC6A3 634/4885
US-20140066446-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 SLC6A2 2308/4885SLC6A4 1650/4885SLC6A3 427/4885
US-20130065889-A1 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 SLC6A2 2308/4885SLC6A4 1650/4885SLC6A3 427/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.