Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.63 |
| ▸ | ABL1 | P00519 | 4/20 | 0.63 |
| ▸ | BCR | P11274 | 4/20 | 0.63 |
| ▸ | ZAP70 | P43403 | 9/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKCG | P05129 | 1/20 | 0.59 |
| ▸ | PRKCB | P05771 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | PRKCH | P24723 | 1/20 | 0.59 |
| ▸ | PRKCI | P41743 | 1/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.59 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | PRKACG | P22612 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956430 | 0.92 | ZAP70 (0.61) | PRKCAABL1BCRZAP70EGFR | |
| SCHEMBL8306459 | 0.88 | ZAP70 (0.56) | PRKCAABL1BCRZAP70EGFR | |
| SCHEMBL6947682 | 0.86 | ZAP70 (0.72) | PRKCAZAP70EGFRPRKCDPRKD3 | |
| SCHEMBL6957800 | 0.84 | ZAP70 (0.66) | PRKCAZAP70EGFRPRKCDPRKD3 | |
| SCHEMBL6952344 | 0.81 | ZAP70 (0.62) | PRKCAZAP70EGFRPRKCDPRKD3 | |
| SCHEMBL8837870 | 0.81 | ABL1 (0.60) | PRKCAABL1BCREGFRPRKCD | |
| SCHEMBL8837810 | 0.81 | PRKCA (0.80) | PRKCAABL1BCREGFRPRKCD | |
| SCHEMBL6947468 | 0.81 | CAMK2D (0.72) | PRKCAABL1BCRZAP70EGFR | |
| SCHEMBL6952728 | 0.81 | ZAP70 (0.65) | PRKCAZAP70EGFRPRKCDPRKD3 | |
| SCHEMBL6955195 | 0.81 | ZAP70 (0.67) | PRKCAABL1BCRZAP70EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552029-B1 | For therapy of rheumatoid arthritis, psoriasis, graft v. host disease, asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, complications following percutaneous transluminal coronary angioplasty, thrombosis | CELLTECH R&D LIMITED (GB) | 2003-04-22 | — | — | US | disclosed |
| EP-0934304-B1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-6114333-A | 2-Pyrimidineamine derivatives and processes for their preparation | CELLTECH THERAPEUTICS LTD. (GB) | 2000-09-05 | — | — | US | disclosed |