Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.47 |
| ▸ | NOTCH1 | P46531 | 12/20 | 0.41 |
| ▸ | NOTCH3 | Q9UM47 | 8/20 | 0.41 |
| ▸ | RBPJ | Q06330 | 4/20 | 0.40 |
| ▸ | CCKAR | P32238 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3593240 | 0.82 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6986032 | 0.80 | NOTCH1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6799982 | 0.77 | KMT2A (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6955221 | 0.70 | NOTCH1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13502677 | 0.66 | PSEN1 (0.97) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6950859 | 0.64 | NOTCH1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7008743 | 0.62 | CCKAR (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL951759 | 0.61 | ALDH1A1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6805380 | 0.61 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16777947 | 0.61 | NOTCH1 (0.49) | NOTCH1NOTCH3RBPJCCKARCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268433-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA-PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074783-A1 | CYCLIC LACTAMS AS INHIBITORS OF A ΒΕΤΑ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |