SCHEMBL6956090

SCHEMBL6956090

CCCCOC(=O)c1ccc(CO)c([N+](=O)[O-])c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 5/20 0.60
ALDH1A1 P00352 4/20 0.55
TDP1 Q9NUW8 1/20 0.55
LMNA P02545 4/20 0.50
CYP1A2 P05177 2/20 0.50
TSHR P16473 2/20 0.50
CYP2C19 P33261 2/20 0.50
MAPT P10636 2/20 0.50
RAB9A P51151 2/20 0.50
PKM P14618 2/20 0.50
NPC1 O15118 1/20 0.50
CRHBP P24387 1/20 0.50
CRHR2 Q13324 1/20 0.50
CYP2D6 P10635 1/20 0.50
MAPK1 P28482 1/20 0.50
NR1H2 P55055 1/20 0.50
RNASEL Q05823 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8821733 0.86 ESR1 (0.56) ESR1ALDH1A1TDP1LMNACYP1A2
SCHEMBL3647689 0.84 ESR1 (0.66) ESR1ALDH1A1LMNACYP1A2TSHR
SCHEMBL10946509 0.83 ESR1 (0.61) ESR1ALDH1A1TDP1LMNACYP1A2
SCHEMBL17287403 0.83 ESR1 (0.61) ESR1ALDH1A1LMNACYP1A2TSHR
SCHEMBL17542258 0.83 ESR1 (0.61) ESR1ALDH1A1TDP1LMNACYP1A2
SCHEMBL25063309 0.81 ESR1 (0.58) ESR1ALDH1A1LMNACYP1A2TSHR
SCHEMBL3085325 0.81 VCAM1 (0.59) ALDH1A1LMNAMAPTRAB9AKMT2A
SCHEMBL16016753 0.81 ESR1 (0.55) ESR1ALDH1A1TDP1LMNACYP1A2
SCHEMBL11495159 0.81 ESR1 (0.57) ESR1ALDH1A1LMNACYP1A2TSHR
SCHEMBL17287371 0.81 ESR1 (0.58) ESR1ALDH1A1TDP1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0751765-B1 SULFONAMIDE DERIVATIVES AND THEIR USE PHARMACOPEIA INC (US) 2003-05-07 EP disclosed
EP-0766826-B1 SYNTHESIS OF COMBINATORIAL LIBRARIES PHARMACOPEIA INC (US) 2002-05-22 EP disclosed
US-5756810-A Process of preparing 3-nitro benzoate compounds in lower alkanol PHARMACOPEIA, INC. (US) 1998-05-26 US disclosed
US-5663046-A DIRECTLY DIVIDING THE CONTENTS OF EACH SUB-POOL INTO THE SUB-POOLS FOR THE NEXT STEP IN THE SYNTHETIC SCHEME REDUCES THE CALCULABLE ERROR FROM THE THAT OF SPLIT SYNTHESIS PHARMACOPEIA, INC. (US) 1997-09-02 US disclosed
US-5618825-A ENZYME INHIBITORS; ANTICOAGULANTS; VISION DISORDERS PHARMACOPEIA, INC. (US) 1997-04-08 US disclosed