Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL694983 | 0.91 | MAPT (0.67) | MAPTRAB9ATDP1L3MBTL1LMNA | |
| SCHEMBL1964237 | 0.85 | MAPT (0.75) | MAPTRAB9ATDP1L3MBTL1LMNA | |
| SCHEMBL695300 | 0.81 | MAPT (0.45) | MAPTRAB9ATDP1L3MBTL1LMNA | |
| SCHEMBL1963632 | 0.79 | MAPT (0.68) | MAPTRAB9ATDP1L3MBTL1LMNA | |
| SCHEMBL695344 | 0.78 | PKM (0.57) | L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1793833 | 0.78 | MAPT (0.66) | MAPTRAB9ATDP1L3MBTL1GAA | |
| SCHEMBL8408614 | 0.77 | MAPT (0.60) | MAPTRAB9ATDP1L3MBTL1LMNA | |
| SCHEMBL1962850 | 0.75 | TDP1 (0.60) | MAPTRAB9ATDP1L3MBTL1LMNA | |
| SCHEMBL2375150 | 0.74 | HPGD (0.51) | MAPTRAB9ATDP1L3MBTL1LMNA | |
| SCHEMBL1951546 | 0.74 | MAPT (1.00) | MAPTRAB9ATDP1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421828-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF RENIN | Cadila Healthcare Limited (IN) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122580-A2 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |