Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2375150 | 0.92 | HPGD (0.51) | MAPTL3MBTL1HPGDMAPK1KDM4E | |
| SCHEMBL695614 | 0.81 | MAPT (0.55) | MAPTL3MBTL1HPGDKDM4EALDH1A1 | |
| SCHEMBL14949910 | 0.76 | KDM4E (0.34) | HPGDKDM4EALDH1A1LMNAUSP2 | |
| SCHEMBL12301074 | 0.75 | HTT (0.37) | PLAU | |
| SCHEMBL4399117 | 0.74 | KDM4E (0.54) | MAPTL3MBTL1KDM4EALDH1A1TDP1 | |
| SCHEMBL17355705 | 0.74 | CA1 (0.45) | MAPTL3MBTL1HPGDMAPK1KDM4E | |
| SCHEMBL17087123 | 0.74 | MAPT (0.53) | MAPTL3MBTL1HPGDMAPK1KDM4E | |
| SCHEMBL2799797 | 0.74 | MAPT (0.53) | MAPTL3MBTL1HPGDMAPK1KDM4E | |
| SCHEMBL660641 | 0.72 | MAPT (0.51) | MAPTL3MBTL1HPGDMAPK1KDM4E | |
| SCHEMBL65612 | 0.72 | MAPT (0.51) | MAPTL3MBTL1HPGDMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085935-A2 | COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2012-06-28 | — | — | WO | disclosed |
| US-20120115907-A1 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2012-05-10 | — | — | US | disclosed |
| EP-2421828-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF RENIN | Cadila Healthcare Limited (IN) | 2012-02-29 | — | — | EP | disclosed |
| EP-2376473-A1 | 3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Merck Canada Inc. (CA) | 2011-10-19 | — | — | EP | disclosed |
| US-20110237622-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2011-09-29 | — | — | US | disclosed |
| US-20110237622-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2011-09-29 | — | — | US | disclosed |
| WO-2010122580-A2 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010066028-A1 | 3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115907-A1 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | REN, ACE, AGTR1 | MAPT 202/4885L3MBTL1 4879/4885HPGD 608/4885 |
| US-20110237622-A1 | RENIN INHIBITORS | REN, ACE, ACE2 | MAPT 4520/4885L3MBTL1 4872/4885HPGD 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.