Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | CDC25C | P30307 | 2/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901176 | 0.85 | CRHBP (0.50) | KCNH2TSHRSIGMAR1 | |
| SCHEMBL2479710 | 0.82 | TSHR (0.54) | KCNH2TSHRSIGMAR1CDC25CMEN1 | |
| SCHEMBL4898565 | 0.80 | KCNH2 (0.67) | KCNH2 | |
| SCHEMBL6961676 | 0.79 | MLYCD (0.47) | KCNH2SIGMAR1MLYCD | |
| SCHEMBL13181406 | 0.79 | MLYCD (0.64) | MLYCDKMT2A | |
| SCHEMBL3534499 | 0.78 | KCNH2 (0.53) | KCNH2TSHRSIGMAR1CDC25CMEN1 | |
| SCHEMBL992030 | 0.78 | KCNH2 (0.50) | KCNH2TSHRSIGMAR1CDC25CMEN1 | |
| SCHEMBL6957942 | 0.78 | KCNH2 (0.64) | KCNH2SIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL6962369 | 0.78 | KCNH2 (0.64) | KCNH2SIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL777298 | 0.76 | KCNH2 (0.60) | KCNH2TSHRSIGMAR1CDC25C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| CN-1071746-C | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 2001-09-26 | — | — | CN | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| CN-1132505-A | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 1996-10-02 | — | — | CN | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |