Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6955381 | 0.97 | SMN1; SMN2 (0.45) | SMN1; SMN2GAAKDM4EALDH1A1LMNA | |
| Acetic Acid SCHEMBL30909179 | 0.97 | SMN1; SMN2 (0.45) | SMN1; SMN2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL6961514 | 0.97 | ALDH1A1 (0.47) | SMN1; SMN2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL30909046 | 0.97 | ALDH1A1 (0.47) | SMN1; SMN2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL6956061 | 0.96 | SMN1; SMN2 (0.48) | SMN1; SMN2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL6962417 | 0.87 | HTR1F (0.45) | SMN1; SMN2GAAKDM4EALDH1A1HTR1F | |
| SCHEMBL30909298 | 0.87 | HTR1F (0.45) | SMN1; SMN2GAAKDM4EALDH1A1HTR1F | |
| SCHEMBL30909221 | 0.84 | HTR1F (0.43) | SMN1; SMN2GAAKDM4EALDH1A1RAB9A | |
| SCHEMBL6962292 | 0.84 | HTR1F (0.43) | SMN1; SMN2GAAKDM4EALDH1A1RAB9A | |
| SCHEMBL30908917 | 0.83 | HTR1F (0.43) | SMN1; SMN2GAAHTR1FTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929299-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA(b)BENZOFURANS | LILLY CO ELI (US) | 2003-10-08 | — | — | EP | disclosed |
| US-5935992-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-08-10 | — | — | US | disclosed |
| US-5932739-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-08-03 | — | — | US | disclosed |
| US-5846995-A | Substituted 1, 2, 3, 4-tetrahydro-2-dibenzofuranamines and 2-amino-cyclohepta (6, 7-B) Benzofurans | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |