Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | PLAU | P00749 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4145911 | 1.00 | DRD2 (0.62) | DRD2DRD3PLAUMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL6953176 | 0.98 | DRD2 (0.61) | DRD2DRD3PLAUMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL6953171 | 0.98 | DRD2 (0.61) | DRD2DRD3PLAUMAPTNFKB1 | |
| SCHEMBL6950353 | 0.92 | OPRK1 (0.62) | DRD2DRD3PLAUMAPTNFKB1 | |
| SCHEMBL4042874 | 0.92 | OPRK1 (0.62) | DRD2DRD3PLAUMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL6958152 | 0.91 | OPRK1 (0.61) | DRD2DRD3PLAUMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL5389505 | 0.91 | OPRK1 (0.61) | DRD2DRD3PLAUMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL5389510 | 0.91 | OPRK1 (0.61) | DRD2DRD3PLAUMAPTNFKB1 | |
| SCHEMBL12607361 | 0.84 | CA1 (0.50) | DRD2DRD3PLAUOPRK1ACHE | |
| SCHEMBL1240585 | 0.84 | CA1 (0.50) | DRD2DRD3PLAUOPRK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757677-B1 | BENZOCYCLOHEXYLIMIDAZOLETHIONE DERIVATIVES | SYNTEX LLC (US) | 2003-06-18 | — | — | EP | disclosed |
| US-5719280-A | REACTING AMINE SUBSTITUTED BENZOCYCLOALKANE WITH DIALKYLOXYACETALDEHYDE IN PRESENCE OF REDUCING AGENT OR CATALYTIC HYDROGENATION, TREATING WITH THIOCYANIC ACID | SYNTEX (U.S.A.) INC. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0757677-A1 | BENZOCYCLOALKYLAZOLETHIONE DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1997-02-12 | — | — | EP | disclosed |
| US-5538988-A | CARDIOVASCULAR DISORDERS AND DOPAMINE HYDROLASE ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. | 1996-07-23 | — | — | US | disclosed |
| WO-1995029165-A2 | BENZOCYCLOALKYLAZ0LETHIONE DERIVATIVES AS DOPAMIN BETA-HYDROXYLASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-11-02 | — | — | WO | disclosed |