Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | HPGD | P15428 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.60 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.58 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272168 | 0.89 | KMT2A (1.00) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL9273340 | 0.88 | KMT2A (0.84) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL9273628 | 0.86 | KMT2A (0.82) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL9271748 | 0.86 | KMT2A (0.82) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL28569414 | 0.85 | ALDH1A1 (0.60) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL14032740 | 0.85 | HTT (0.82) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL14112020 | 0.85 | KMT2A (0.79) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL9271522 | 0.84 | ALDH1A1 (0.82) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL10594022 | 0.84 | KMT2A (0.77) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL1695939 | 0.83 | KMT2A (0.88) | KMT2AHPGDALDH1A1CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759564-B | Diaryl urea compound and its prepn and medicinal use | 中国医学科学院药物研究所 | 2023-09-26 | — | — | CN | disclosed |
| CN-112759564-A | Diaryl urea compound and its preparation method and medicinal use | 中国医学科学院药物研究所 | 2021-05-07 | — | — | CN | disclosed |
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |