Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737149 | 1.00 | FUCA1 (0.47) | FUCA1MC4RSIGMAR1ACHEOPRM1 | |
| SCHEMBL18713027 | 0.90 | FUCA1 (0.53) | FUCA1MC4RSIGMAR1ACHEOPRM1 | |
| SCHEMBL1022483 | 0.83 | OPRM1 (0.54) | FUCA1MC4RSIGMAR1ACHEOPRM1 | |
| SCHEMBL6959368 | 0.81 | FUCA1 (0.47) | FUCA1MC4RSIGMAR1ACHEOPRM1 | |
| SCHEMBL1022425 | 0.80 | FUCA1 (0.50) | FUCA1MC4RSIGMAR1ACHEOPRM1 | |
| Hydrochloric Acid SCHEMBL11776272 | 0.80 | OPRM1 (0.51) | FUCA1MC4RSIGMAR1ACHEOPRM1 | |
| SCHEMBL1449589 | 0.80 | FUCA1 (0.50) | FUCA1MC4RSIGMAR1ACHEOPRM1 | |
| SCHEMBL20936788 | 0.80 | FUCA1 (0.53) | FUCA1SIGMAR1ACHES1PR1S1PR5 | |
| SCHEMBL20937473 | 0.80 | FUCA1 (0.53) | FUCA1SIGMAR1ACHES1PR1S1PR5 | |
| SCHEMBL17304830 | 0.79 | FUCA1 (0.56) | FUCA1SIGMAR1ACHES1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550550-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | claimed |
| WO-1992005174-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | claimed |
| EP-0550550-B1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 2003-07-16 | — | — | EP | disclosed |
| EP-0558923-B1 | Diazabicyclo derivatives as 5-HT3 antagonists | NISSHIN FLOUR MILLING CO (JP) | 2000-05-24 | — | — | EP | disclosed |
| US-5344831-A | Antiemetics for treatment of nausea from chemotherapy | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0558923-A1 | Diazabicyclo derivatives as 5-HT3 antagonists | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-09-08 | — | — | EP | disclosed |
| EP-0550550-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1993007147-A1 | 3,9-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES WITH 5-HT3 RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1993-04-15 | — | — | WO | disclosed |
| WO-1992005174-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |