Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954336 | 1.00 | HTR6 (0.32) | HTR6HCRTR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6954328 | 1.00 | HTR6 (0.32) | HTR6HCRTR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6958706 | 0.89 | EPAS1 (0.32) | HCRTR2 | |
| SCHEMBL4370917 | 0.89 | EPAS1 (0.32) | HCRTR2 | |
| SCHEMBL6954469 | 0.89 | EPAS1 (0.32) | HCRTR2 | |
| SCHEMBL8613236 | 0.87 | PARP1 (0.30) | — | |
| SCHEMBL6951218 | 0.79 | HDAC8 (0.32) | — | |
| SCHEMBL6954106 | 0.79 | FPR2 (0.32) | — | |
| SCHEMBL6951811 | 0.78 | HTR1D (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL6957834 | 0.78 | HTR1D (0.45) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757677-B1 | BENZOCYCLOHEXYLIMIDAZOLETHIONE DERIVATIVES | SYNTEX LLC (US) | 2003-06-18 | — | — | EP | disclosed |
| US-5719280-A | REACTING AMINE SUBSTITUTED BENZOCYCLOALKANE WITH DIALKYLOXYACETALDEHYDE IN PRESENCE OF REDUCING AGENT OR CATALYTIC HYDROGENATION, TREATING WITH THIOCYANIC ACID | SYNTEX (U.S.A.) INC. (US) | 1998-02-17 | — | — | US | disclosed |
| US-5538988-A | CARDIOVASCULAR DISORDERS AND DOPAMINE HYDROLASE ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. | 1996-07-23 | — | — | US | disclosed |