Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.78 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.78 |
| ▸ | ITGAV | P06756 | 16/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676238 | 1.00 | ITGB3 (0.78) | ITGB3ITGA2BITGAV | |
| SCHEMBL6958161 | 1.00 | ITGB3 (0.78) | ITGB3ITGA2BITGAV | |
| SCHEMBL7544147 | 0.95 | ITGB3 (0.71) | ITGB3ITGA2BITGAV | |
| SCHEMBL8525426 | 0.92 | ITGB3 (0.65) | ITGB3ITGA2BITGAV | |
| Lotrafiban SCHEMBL6673128 | 0.88 | ITGB3 (1.00) | ITGB3ITGA2BITGAV | |
| Lotrafiban SCHEMBL6673166 | 0.88 | ITGB3 (1.00) | ITGB3ITGA2BITGAV | |
| SCHEMBL6690645 | 0.88 | ITGB3 (0.79) | ITGB3ITGA2BITGAV | |
| Lotrafiban SCHEMBL919968 | 0.87 | ITGB3 (0.98) | ITGB3ITGA2BITGAV | |
| Lotrafiban SCHEMBL4432242 | 0.86 | ITGB3 (0.96) | ITGB3ITGA2BITGAV | |
| SCHEMBL7916977 | 0.86 | ITGB3 (0.74) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738150-B1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6117866-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| EP-0738150-A4 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0738150-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-23 | — | — | EP | disclosed |
| WO-1995018619-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-07-13 | — | — | WO | disclosed |