Lotrafiban

Lotrafiban

SCHEMBL6673166

CN1Cc2cc(C(=O)N3CCC(C4CCNCC4)CC3)ccc2NC(CC(=O)O)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 20/20 1.00
ITGA2B P08514 14/20 1.00
ITGAV P06756 16/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lotrafiban SCHEMBL29596 1.00 ITGB3 (1.00) ITGB3ITGA2BITGAV
Lotrafiban SCHEMBL6673128 1.00 ITGB3 (1.00) ITGB3ITGA2BITGAV
Lotrafiban SCHEMBL919968 0.99 ITGB3 (0.98) ITGB3ITGA2BITGAV
Lotrafiban SCHEMBL4432242 0.98 ITGB3 (0.96) ITGB3ITGA2BITGAV
SCHEMBL7499918 0.92 ITGB3 (0.85) ITGB3ITGA2BITGAV
SCHEMBL8526301 0.90 ITGB3 (0.82) ITGB3ITGA2BITGAV
SCHEMBL8194605 0.90 ITGB3 (0.82) ITGB3ITGA2BITGAV
SCHEMBL6675548 0.88 ITGB3 (0.79) ITGB3ITGA2BITGAV
SCHEMBL6958161 0.88 ITGB3 (0.78) ITGB3ITGA2BITGAV
SCHEMBL6958164 0.88 ITGB3 (0.78) ITGB3ITGA2BITGAV

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995018619-A9 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2004-10-21 WO claimed
EP-0738150-B1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-02 EP claimed
WO-2000063186-A1 PROCESS AND INTERMEDIATES FOR PREPARING BENZODIAZEPINES SMITHKLINE BEECHAM PLC (GB) 2000-10-26 WO claimed
US-6117866-A Bicyclic fibrinogen antagonists SMITHKLINE BEECHAM CORPORATION (US) 2000-09-12 US claimed
EP-1003514-A1 CYCLIC AMINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2000-05-31 EP claimed
WO-1999004794-A1 CYCLIC AMINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1999-02-04 WO claimed
EP-0738150-A4 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 1997-03-19 EP claimed
EP-0738150-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-10-23 EP claimed
WO-1995018619-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1995-07-13 WO claimed
WO-1995018619-A9 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2004-10-21 WO disclosed
EP-0738150-B1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-02 EP disclosed
WO-2000063186-A1 PROCESS AND INTERMEDIATES FOR PREPARING BENZODIAZEPINES SMITHKLINE BEECHAM PLC (GB) 2000-10-26 WO disclosed
US-6117866-A Bicyclic fibrinogen antagonists SMITHKLINE BEECHAM CORPORATION (US) 2000-09-12 US disclosed
EP-0738150-A4 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 1997-03-19 EP disclosed
EP-0738150-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-10-23 EP disclosed
WO-1995018619-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1995-07-13 WO disclosed