Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTR1B | P28222 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952620 | 0.96 | HTR1F (0.66) | HTR1FRAB9AKMT2AHTR1BHTR1A | |
| SCHEMBL9333438 | 0.87 | HTR1F (0.68) | HTR1FRAB9AKMT2AHTR1BHTR1A | |
| SCHEMBL6950544 | 0.86 | KMT2A (0.72) | HTR1FRAB9AKMT2AHTR1BHTR1A | |
| Oxalic Acid SCHEMBL6959601 | 0.84 | KMT2A (0.51) | HTR1FRAB9AKMT2AHTR1BHTR1A | |
| Oxalic Acid SCHEMBL9334173 | 0.84 | HTR1F (0.64) | HTR1FRAB9AKMT2AHTR1BHTR1A | |
| SCHEMBL7657715 | 0.83 | HTR1F (0.69) | HTR1FRAB9AKMT2AHTR1BHTR1A | |
| Hydrochloric Acid SCHEMBL6963197 | 0.81 | HTR1F (0.68) | HTR1FRAB9AKMT2AHTR1BHTR1A | |
| SCHEMBL6965193 | 0.81 | HTR1A (0.56) | RAB9AKMT2AHTR1BHTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL6954125 | 0.80 | HTR1F (0.67) | HTR1FRAB9AKMT2AHTR1BHTR1A | |
| SCHEMBL7408877 | 0.80 | HTR1F (0.59) | HTR1FRAB9AKMT2AHTR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882726-B1 | Carbazol-carboxamides as 5-HT1F agonists | LILLY CO ELI (US) | 2003-05-21 | — | — | EP | disclosed |
| US-6221884-B1 | Carboxamides useful as 5-HT1F agonists | ELI LILLY AND COMPANY | 2001-04-24 | — | — | US | disclosed |
| EP-0882726-A1 | Carbazol-carboxamides as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-12-09 | — | — | EP | disclosed |