SCHEMBL6958413

SCHEMBL6958413

CCc1ccc2c[c][nH]c2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.45
CYP2A6 P11509 1/20 0.45
DAO P14920 1/20 0.45
KIF11 P52732 1/20 0.42
AKR1C3 P42330 1/20 0.38
AKR1C2 P52895 1/20 0.38
TRPA1 O75762 1/20 0.38
SMN1; SMN2 Q16637 4/20 0.35
MAPT P10636 3/20 0.34
ALDH1A1 P00352 3/20 0.34
HTR1A P08908 2/20 0.33
HTR1D P28221 2/20 0.33
HTR1B P28222 2/20 0.33
ELANE P08246 1/20 0.33
TYMS P04818 1/20 0.33
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
LMNA P02545 1/20 0.32
MAPK1 P28482 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17844466 0.86 CYP1A2 (0.47) CYP1A2CYP2A6DAOKIF11AKR1C3
SCHEMBL4693144 0.80 MEN1 (0.31)
SCHEMBL9740137 0.76 IDH1 (0.43)
SCHEMBL2486090 0.76 XDH (0.43) CYP1A2SMN1; SMN2MAPTALDH1A1LMNA
SCHEMBL207188 0.72 CYP1A2 (0.46) CYP1A2CYP2A6DAOKIF11MAPT
SCHEMBL6955320 0.72 HPGD (0.53) CYP1A2AKR1C3AKR1C2SMN1; SMN2MAPT
SCHEMBL347592 0.70 CYP2A6 (0.80) CYP1A2CYP2A6DAOKIF11AKR1C3
SCHEMBL29407167 0.70 CYP2A6 (0.80) CYP1A2CYP2A6DAOKIF11AKR1C3
SCHEMBL9739501 0.70 CA12 (0.51) CYP1A2SMN1; SMN2MAPTALDH1A1NPC1
SCHEMBL31271 0.69 AHR (0.50) CYP1A2CYP2A6DAOKIF11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6333339-B1 CENTRAL SYSTEM DISORDERS, SCHIZOPHRENIA AND COGNITION ACTIVATORS MERCK PATENT GELLSCHAFT MIT BESCHRANKTER (DE) 2001-12-25 US claimed
EP-0993458-B1 3-BENZYLPIPERIDINE MERCK PATENT GMBH (DE) 2003-04-09 EP disclosed
US-6333339-B1 CENTRAL SYSTEM DISORDERS, SCHIZOPHRENIA AND COGNITION ACTIVATORS MERCK PATENT GELLSCHAFT MIT BESCHRANKTER (DE) 2001-12-25 US disclosed
EP-0998474-A1 PIPERAZINE DERIVATIVES MERCK PATENT GmbH (DE) 2000-05-10 EP disclosed
EP-0993458-A1 3-BENZYLPIPERIDINE MERCK PATENT GmbH (DE) 2000-04-19 EP disclosed
WO-1999003855-A1 PIPERAZINE DERIVATIVES MERCK PATENT GMBH (DE) 1999-01-28 WO disclosed
WO-1998057953-A1 3-BENZYLPIPERIDINE MERCK PATENT GMBH (DE) 1998-12-23 WO disclosed