SCHEMBL6958458

SCHEMBL6958458

O=C(O)Oc1ccc2cnccc2c1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 11/20 0.49
IMPDH2 P12268 4/20 0.49
MRGPRX4 Q96LA9 1/20 0.47
CYP1A2 P05177 1/20 0.46
CYP2C19 P33261 1/20 0.46
PRKCZ Q05513 1/20 0.43
ROCK1 Q13464 2/20 0.43
ROCK2 O75116 1/20 0.43
MEN1 O00255 1/20 0.42
MAPT P10636 1/20 0.42
KMT2A Q03164 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9828031 0.88 CYP3A4 (0.50) CYP3A4IMPDH2CYP1A2CYP2C19ROCK2
SCHEMBL9826855 0.83 CA12 (0.49) CYP3A4MRGPRX4CYP1A2CYP2C19MEN1
SCHEMBL19641879 0.83 CYP3A4 (0.49) CYP3A4IMPDH2MRGPRX4CYP1A2CYP2C19
SCHEMBL809274 0.82 KMT2A (0.55) MEN1MAPTKMT2ATDP1
SCHEMBL28344471 0.82 KMT2A (0.69) CYP3A4IMPDH2MRGPRX4CYP1A2CYP2C19
SCHEMBL8414749 0.81 CYP3A4 (0.51) CYP3A4IMPDH2ROCK2
SCHEMBL29472082 0.79 CYP3A4 (0.57) CYP3A4CYP1A2CYP2C19ROCK2MEN1
SCHEMBL6630095 0.79 IMPDH2 (0.64) IMPDH2ROCK1ROCK2MEN1KMT2A
SCHEMBL11298874 0.78 KMT2A (0.52) MEN1MAPTKMT2ATDP1
SCHEMBL4423206 0.78 KMT2A (0.57) MEN1MAPTKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0863875-B1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY HOFFMANN LA ROCHE (CH) 2003-06-04 EP disclosed
EP-0863875-A1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY F. HOFFMANN-LA ROCHE AG (CH) 1998-09-16 EP disclosed
EP-0707656-B1 BIOTECHNOLOGICAL PROCESS FOR PRODUCING ALCOHOLS, ALDEHYDES AND CARBOXYLIC ACIDS BASF AG (DE) 1998-09-02 EP disclosed
WO-1997009311-A1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY F. HOFFMANN-LA ROCHE AG (CH) 1997-03-13 WO disclosed