Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NMBR | P28336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12510626 | 0.81 | SIRT2 (0.36) | SIRT2ENPP2CYP11B1CYP11B2KDM4E | |
| SCHEMBL5682164 | 0.81 | CYP11B1 (0.43) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL28146943 | 0.81 | SIRT2 (0.36) | SIRT2ENPP2CYP11B1CYP11B2KDM4E | |
| SCHEMBL7803975 | 0.80 | SIRT2 (0.35) | SIRT2ENPP2CYP11B1CYP11B2NMBR | |
| SCHEMBL7641514 | 0.79 | P2RX7 (0.40) | SIRT2ENPP2CYP11B1CYP11B2KDM4E | |
| SCHEMBL7803955 | 0.79 | NPC1 (0.36) | SIRT2ENPP2 | |
| SCHEMBL7978828 | 0.78 | LCK (0.38) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL1040045 | 0.76 | CYP11B1 (0.41) | SIRT2ENPP2CYP11B1CYP11B2KDM4E | |
| SCHEMBL670904 | 0.75 | CYP11B1 (0.43) | SIRT2ENPP2CYP11B1CYP11B2KDM4E | |
| SCHEMBL2203209 | 0.75 | CDC25B (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0954521-B1 | 4- (THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO MCNEIL PHARM INC (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0954521-A1 | 4- (THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | Ortho-McNeil Pharmaceutical, Inc. (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5750720-A | ALPHA-ADRENORECEPTORS AND CENTRAL NERVOUS SYSTEMS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1997035858-A1 | 4-[(THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING α2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |