Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.52 |
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6958640 | 0.80 | NOS1 (0.52) | NPC1RAB9ASMN1; SMN2RECQLMGLL | |
| SCHEMBL9038704 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2ROCK2MEN1 | |
| SCHEMBL6962657 | 0.80 | TRPV1 (0.55) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| Iodide SCHEMBL6962649 | 0.79 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2ROCK2MEN1 | |
| SCHEMBL7081200 | 0.78 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2TSHRMEN1 | |
| Phenethyl Phenylcarbamate SCHEMBL1835027 | 0.78 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2RECQLMGLL | |
| SCHEMBL6280367 | 0.78 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9037372 | 0.78 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL4627573 | 0.77 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2ROCK2MEN1 | |
| SCHEMBL4627215 | 0.77 | TRPV1 (0.52) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | claimed |
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |