Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR1B | P28222 | 3/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959010 | 0.84 | HTR1F (0.65) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| SCHEMBL2359786 | 0.83 | HTR1A (0.60) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| SCHEMBL7743816 | 0.83 | HTR1A (0.60) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| SCHEMBL9265318 | 0.83 | HTR1A (0.60) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| Formic Acid SCHEMBL6962862 | 0.82 | HTR1B (0.49) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| SCHEMBL6952624 | 0.82 | HTR1A (0.59) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL9263041 | 0.82 | HTR1A (0.59) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| SCHEMBL7657219 | 0.81 | HTR1F (0.51) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| SCHEMBL7657721 | 0.81 | HTR1A (0.62) | HTR1AHTR1BHTR1DALDH1A1LMNA | |
| SCHEMBL7665360 | 0.81 | HTR1F (0.58) | HTR1AHTR1BHTR1DALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882726-B1 | Carbazol-carboxamides as 5-HT1F agonists | LILLY CO ELI (US) | 2003-05-21 | — | — | EP | disclosed |
| US-6221884-B1 | Carboxamides useful as 5-HT1F agonists | ELI LILLY AND COMPANY | 2001-04-24 | — | — | US | disclosed |
| EP-0882726-A1 | Carbazol-carboxamides as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-12-09 | — | — | EP | disclosed |