Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7591012 | 0.99 | REN (0.54) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6043116 | 0.90 | REN (0.54) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6043664 | 0.84 | REN (0.61) | RENSLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL6042922 | 0.82 | REN (0.59) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7076347 | 0.81 | REN (0.51) | REN | |
| SCHEMBL6042189 | 0.79 | REN (0.43) | REN | |
| SCHEMBL6954219 | 0.76 | REN (0.60) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6042395 | 0.76 | REN (0.80) | REN | |
| Hydrochloric Acid SCHEMBL8207725 | 0.76 | REN (0.59) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6958296 | 0.75 | REN (0.52) | RENSLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1256326-C | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | CN | disclosed |
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |