Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 2/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | FCER2 | P06734 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30843262 | 0.93 | CYP1A2 (0.50) | CYP1A2CYP2A6CYP19A1SLC6A2SLC6A4 | |
| SCHEMBL2287085 | 0.93 | CYP1A2 (0.50) | CYP1A2CYP2A6CYP19A1SLC6A2SLC6A4 | |
| SCHEMBL2888187 | 0.86 | CYP1A2 (0.42) | CYP1A2CYP2A6BCHEACHE | |
| SCHEMBL31069470 | 0.86 | CYP1A2 (0.42) | CYP1A2CYP2A6BCHEACHE | |
| SCHEMBL9718376 | 0.83 | SLC6A2 (0.45) | CYP1A2CYP2A6CYP19A1SLC6A2SLC6A4 | |
| SCHEMBL9226931 | 0.80 | CYP1A2 (0.35) | CYP1A2CYP2A6CYP19A1SLC6A2SLC6A4 | |
| SCHEMBL5349984 | 0.79 | CYP1A2 (0.41) | CYP1A2CYP2A6SLC6A2SLC6A3BCHE | |
| SCHEMBL6233504 | 0.78 | LOXL2 (0.56) | CYP1A2CYP2A6CYP19A1SLC6A2SLC6A4 | |
| SCHEMBL8499490 | 0.78 | CYP1A2 (0.48) | CYP1A2CYP2A6CYP19A1SLC6A2SLC6A4 | |
| SCHEMBL14604942 | 0.78 | CYP1A2 (0.59) | CYP1A2CYP2A6CYP19A1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183907-C | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | SERVIER LAB (FR) | 2005-01-12 | — | — | CN | disclosed |
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| CN-1257864-A | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | ADIR (FR) | 2000-06-28 | — | — | CN | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | disclosed |
| EP-0375368-B1 | Alcohol and ether derivatives | ZENECA LTD (GB) | 1995-08-16 | — | — | EP | disclosed |
| US-5407945-A | Pyran derivatives and their use as inhibitors of 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES, INC. (GB) | 1995-04-18 | — | — | US | disclosed |
| US-5403859-A | PHENYLENE-CYCLIC ETHER COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-04 | — | — | US | disclosed |
| EP-0375452-B1 | Cycloalkane derivatives | ICI PLC (GB) | 1994-10-05 | — | — | EP | disclosed |
| US-5105020-A | Lopoxygerase inhibitors; antiinflammatory agents, antiallergens | IMPERIAL CHEMISTRIES INDUSTRIES PLC (GB) | 1992-04-14 | — | — | US | disclosed |
| US-5098932-A | Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC, ICI PHARMA (FR) | 1992-03-24 | — | — | US | disclosed |
| US-5098930-A | Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-03-24 | — | — | US | disclosed |
| US-5089513-A | Antiinflammatory agents; antiallergens; asthma; side effect reduction | ICI PHARMA (FR) | 1992-02-18 | — | — | US | disclosed |
| EP-0462830-A2 | Cyclic ether derivatives | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |
| EP-0375457-A2 | Cyclic ether derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0375368-A2 | Alcohol and ether derivatives | ZENECA LIMITED (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0375452-A2 | Cycloalkane derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0375404-A2 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0351194-A2 | Thiazole derivatives having a 5-lipoxygenase-inhibiting activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-01-17 | — | — | EP | disclosed |