Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.43 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956176 | 1.00 | CTSK (0.50) | CTSKKCNA3KDM4DCCRL2CCR2 | |
| SCHEMBL6959302 | 1.00 | CTSK (0.50) | CTSKKCNA3KDM4DCCRL2CCR2 | |
| SCHEMBL7841697 | 0.81 | CTSK (0.47) | CTSKKCNA3KDM4DOPRM1OPRD1 | |
| SCHEMBL1808105 | 0.80 | CTSK (0.61) | CTSKKCNA3OPRM1OPRD1OPRK1 | |
| SCHEMBL1699915 | 0.80 | CTSK (0.61) | CTSKKCNA3OPRM1OPRD1OPRK1 | |
| SCHEMBL1699916 | 0.80 | CTSK (0.61) | CTSKKCNA3OPRM1OPRD1OPRK1 | |
| SCHEMBL12835989 | 0.79 | PIM1 (0.58) | CTSKKCNA3KDM4DSUV39H2KMT2A | |
| SCHEMBL803320 | 0.78 | CTSK (0.58) | CTSKOPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL2464322 | 0.77 | KCNA3 (0.57) | CTSKKCNA3OPRM1OPRD1OPRK1 | |
| SCHEMBL7964848 | 0.77 | DRD4 (0.44) | CTSKKCNA3OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |