Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylmethanesulfonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.56 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylmethanesulfonic Acid SCHEMBL135008 | 0.97 | CA2 (0.58) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL340526 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL5858462 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL7098601 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL2057826 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL1565755 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL9812588 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL7208342 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL18419593 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 | |
| Phenylmethanesulfonic Acid SCHEMBL18419589 | 0.95 | CA2 (0.56) | CA2CA1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974582-B1 | Process for the preparation of 4-substituted azetidinone derivatives | TAKASAGO PERFUMERY CO LTD (JP) | 2003-02-12 | — | — | EP | claimed |