Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963441 | 0.85 | PTPN1 (0.57) | CFTRKDM4EMAPTRECQLNPSR1 | |
| SCHEMBL6428107 | 0.83 | CFTR (0.50) | CFTRKDM4EMAPTRECQLNPSR1 | |
| SCHEMBL2726214 | 0.80 | CFTR (0.58) | CFTRKDM4EMAPTRECQLNPSR1 | |
| SCHEMBL6959703 | 0.78 | CFTR (0.51) | CFTRKDM4EMAPTRECQLNPSR1 | |
| SCHEMBL28366655 | 0.77 | KDM4E (0.56) | CFTRKDM4EALDH1A1POLBNR4A2 | |
| SCHEMBL4134287 | 0.75 | KDM4E (0.54) | CFTRKDM4EMAPTALDH1A1POLB | |
| SCHEMBL6967431 | 0.74 | MAPT (0.37) | KDM4EMAPTRECQLNPSR1PTPN1 | |
| SCHEMBL6963860 | 0.73 | CFTR (0.52) | CFTRKDM4EMAPTRECQLNPSR1 | |
| SCHEMBL1958004 | 0.73 | SLC6A3 (0.58) | KDM4EMAPTALDH1A1GAARAB9A | |
| SCHEMBL2770705 | 0.73 | HPGD (0.47) | KDM4EMAPTNPSR1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649636-B1 | Cyclooxygenase inhibitors | PFIZER INC. | 2003-11-18 | — | — | US | disclosed |
| EP-1104759-B1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1104759-A1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |