Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959707 | 0.85 | CFTR (0.49) | PTPN1CFTRKDM4EALDH1A1POLB | |
| SCHEMBL6426460 | 0.79 | PTPN1 (0.60) | PTPN1PTPN2PTPN6CFTRKDM4E | |
| SCHEMBL6970043 | 0.74 | KDM4E (0.41) | PTPN1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL6967431 | 0.74 | MAPT (0.37) | PTPN1PTPN2PTPN6KDM4EALDH1A1 | |
| SCHEMBL6963436 | 0.74 | PTPN1 (0.49) | PTPN1PTPN2PTPN6CFTRKDM4E | |
| SCHEMBL1673212 | 0.73 | PTPN1 (0.54) | PTPN1PTPN2PTPN6CFTRKDM4E | |
| SCHEMBL8384592 | 0.72 | KLKB1 (0.47) | FOLH1ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL4141035 | 0.71 | PTPN1 (0.51) | PTPN1PTPN2PTPN6CFTRKDM4E | |
| SCHEMBL28650005 | 0.68 | MRGPRX4 (0.49) | PTPN1KDM4EALDH1A1RCE1 | |
| SCHEMBL28869121 | 0.68 | PTPN1 (0.52) | PTPN1PTPN2PTPN6CFTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649636-B1 | Cyclooxygenase inhibitors | PFIZER INC. | 2003-11-18 | — | — | US | disclosed |
| EP-1104759-B1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1104759-A1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |