SCHEMBL6959780

SCHEMBL6959780

O=C1CCC(COCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.59
SLC6A4 P31645 15/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6483011 0.88 TACR1 (0.76) TACR1SLC6A4
SCHEMBL8121377 0.85 TACR1 (0.78) TACR1SLC6A4
SCHEMBL3893200 0.84 TACR1 (0.77) TACR1SLC6A4
SCHEMBL5374540 0.81 TACR1 (0.71) TACR1SLC6A4
SCHEMBL8115347 0.78 TACR1 (0.62) TACR1SLC6A4
SCHEMBL6482875 0.77 TACR1 (0.59) TACR1SLC6A4
SCHEMBL5592015 0.76 TACR1 (0.60) TACR1SLC6A4
SCHEMBL6481909 0.76 TACR1 (0.79) TACR1
SCHEMBL12679398 0.76 TACR1 (0.79) TACR1
SCHEMBL5388727 0.75 TACR1 (0.73) TACR1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1286978-A1 CYCLOHEXYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS MERCK SHARP & DOHME LTD. (GB) 2003-03-05 EP disclosed
WO-2001087866-A1 CYCLOHEXYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS MERCK SHARP & DOHME LIMITED (GB) 2001-11-22 WO disclosed