Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389069 | 0.81 | TACR1 (0.62) | TACR1 | |
| SCHEMBL6959780 | 0.78 | TACR1 (0.59) | TACR1SLC6A4 | |
| SCHEMBL8121377 | 0.77 | TACR1 (0.78) | TACR1SLC6A4 | |
| SCHEMBL1388352 | 0.77 | TACR1 (0.84) | TACR1SLC6A4 | |
| SCHEMBL1388353 | 0.74 | TACR1 (0.69) | TACR1SLC6A4 | |
| SCHEMBL5592015 | 0.73 | TACR1 (0.60) | TACR1SLC6A4 | |
| SCHEMBL8920066 | 0.72 | TACR1 (0.73) | TACR1SLC6A4 | |
| SCHEMBL14541330 | 0.70 | TACR1 (0.64) | TACR1SLC6A4 | |
| SCHEMBL5592022 | 0.70 | TACR1 (0.73) | TACR1SLC6A4 | |
| SCHEMBL1388284 | 0.69 | TACR1 (1.00) | TACR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666856-B1 | 4-ARYLMETHYLOXYMETHYL PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME (GB) | 2000-01-05 | — | — | EP | disclosed |
| US-5620989-A | NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; PARTICULARLY ANTAGONISTIC FOR SUBSTANCE P | MERCK SHARP & DOHME LIMITED (GB) | 1997-04-15 | — | — | US | disclosed |
| WO-1994010165-A1 | 4-ARYLMETHYLOXYMETHYL PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-05-11 | — | — | WO | disclosed |